Related Experiment Video
Updated: Aug 25, 2026

Facile Preparation and Photoactivation of Prodrug-Dye Nanoassemblies
Published on: February 17, 2023
New chemical adaptor unit designed to release a drug from a tumor targeting device by enzymatic triggering
Anna Gopin1, Christoph Rader, Doron Shabat
1School of Chemistry, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel Aviv 69978, Israel.
Abstract:
A new controlled drug delivery system for selective chemotherapy was developed. It is based on a chemical adaptor unit, that releases a drug by a spontaneous cyclization mechanism after cleavage of an enzymatic substrate. It also provides a generic linkage of a drug with a targeting device in a manner set to be triggered by defined enzymatic activity. The system is generic and allows using a variety of drugs, targeting devices, and enzymes by introducing the corresponding substrate as a trigger for drug release in the chemical adaptor.
Related Concept Videos
Modified-Release Drug Delivery Systems: Stimuli-Activated
Modified-Release Drug Delivery Systems: Site-Targeted
Modified-Release Drug Delivery Systems: Classification
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Modified-Release Drug Delivery Systems: Rate-Programmed II