Related Experiment Video

Updated: Aug 25, 2026

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model
10:32

Monitoring Dynamic Growth of Retinal Vessels in Oxygen-Induced Retinopathy Mouse Model

Published on: April 2, 2021

[Retinopathy of prematurity]

C Jandeck1, U Kellner, M H Foerster

  • 1Universitätsaugenklinik Charité - Universitätsmedizin Berlin, Berlin. claudia.jandeck@charite.de

Klinische Monatsblatter Fur Augenheilkunde
|March 31, 2004
PubMed

Insights

Retinopathy of prematurity (ROP) remains a significant concern despite advances in neonatal care. Early ophthalmologic screening and timely laser treatment for advanced ROP are crucial for preventing blindness in premature infants.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Pediatric Medicine

Context:

  • Premature infants face significant risks for vision impairment, particularly retinopathy of prematurity (ROP).
  • Advances in neonatal intensive care have increased survival rates of extremely premature infants, but ROP incidence remains high.
  • ROP is a leading cause of preventable childhood blindness globally.

Purpose:

  • To review current knowledge and recent clinical advances in retinopathy of prematurity (ROP).
  • To discuss the pathophysiology, classification, and epidemiology of ROP.
  • To summarize treatment strategies, outcomes, and future therapeutic options for ROP.

Summary:

  • This review covers the history, classification, and pathophysiology of ROP.
  • It summarizes findings from multicenter treatment trials and discusses current screening guidelines (German and international).
  • Therapeutic strategies, treatment outcomes, and potential future therapies like anti-angiogenic factors are explored.

Impact:

  • Highlights the importance of timely ophthalmologic screening and laser treatment in preventing ROP-related blindness.
  • Addresses the long-term ophthalmologic sequelae in preterm infants, including amblyopia, strabismus, and refractive errors.
  • Informs clinical practice and research directions for managing and potentially preventing retinopathy of prematurity.

More Related Videos

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents09:28

Oxygen-Induced Retinopathy Model for Ischemic Retinal Diseases in Rodents

Published on: September 16, 2020

Transcutaneous Microcirculatory Imaging in Preterm Neonates06:27

Transcutaneous Microcirculatory Imaging in Preterm Neonates

Published on: December 31, 2015

Related Concept Videos

Diabetic Retinopathy01:27

Diabetic Retinopathy

DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
The Retina01:32

The Retina

The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...