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Myelofibrosis secondary to hyperparathyroidism
B Kumbasar1, I Taylan, R Kazancioglu
1Haseki Training and Research Hospital, Department of Internal Medicine, Istanbul, Turkey. abakikumbasar@yahoo.com
Summary
Primary hyperparathyroidism can cause myelofibrosis and anemia. Surgical removal of a parathyroid adenoma resolved these conditions, indicating a direct link between the endocrine disorder and bone marrow fibrosis.
Area of Science:
- Endocrinology
- Hematology
- Oncology
Background:
- Primary hyperparathyroidism is a condition characterized by excessive parathyroid hormone production.
- It can lead to various systemic complications, including hematological abnormalities.
- The association between primary hyperparathyroidism and myelofibrosis is rarely reported.
Observation:
- A young female presented with fatigue, bilateral knee pain, and gait disturbance.
- Investigations revealed primary hyperparathyroidism, splenomegaly, anemia, and myelofibrosis on bone marrow biopsy.
- A parathyroid adenoma was surgically removed.
Findings:
- Post-surgery, significant improvement in hematologic parameters and bone markers was observed within three months.
- A follow-up bone marrow biopsy showed marked regression of myelofibrosis.
- Splenomegaly also gradually decreased.
Implications:
- This case suggests that myelofibrosis can be a direct consequence of primary hyperparathyroidism.
- Anemia in primary hyperparathyroidism may be attributed to associated bone marrow fibrosis.
- Early diagnosis and treatment of primary hyperparathyroidism can potentially reverse myelofibrosis and related complications.