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[Unilateral open lip schizencephaly between central sulcus and third ventricle].

Kader Karli Oğuz1, Ayşenur Cila, Tuncay Hazirolan

  • 1Hacettepe Universitesi Tip Fakültesi, Radyoloji Anabilim Dali, Ankara, Turkey.

Tanisal Ve Girisimsel Radyoloji : Tibbi Goruntuleme Ve Girisimsel Radyoloji Dernegi Yayin Organi
|April 1, 2004
PubMed
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This study details a rare case of open lip schizencephaly in a 12-year-old boy. The brain MRI revealed a significant cleft and associated neuronal migration anomalies.

Area of Science:

  • Neurology
  • Radiology
  • Developmental Neuroscience

Background:

  • Schizencephaly is a congenital brain malformation characterized by a cleft in the cerebral hemisphere.
  • Neuronal migration anomalies are frequently associated with schizencephaly, impacting brain development.
  • Imaging modalities like MRI are crucial for diagnosing these complex conditions.

Observation:

  • A 12-year-old male patient presented with neurological symptoms.
  • Brain Magnetic Resonance Imaging (MRI) was performed for diagnostic evaluation.
  • The MRI revealed findings consistent with open lip schizencephaly.

Findings:

  • The transcerebral cleft extended from the third ventricle to the hemisphere's pial surface.
  • Associated findings included other neuronal migration anomalies.

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  • Complete agenesis of the corpus callosum was also identified.
  • Implications:

    • This case highlights the spectrum of imaging findings in schizencephaly.
    • Understanding these malformations is vital for accurate diagnosis and patient management.
    • Further research into the genetic and developmental underpinnings of these anomalies is warranted.