Related Experiment Video
Updated: Aug 25, 2026

Differentiating Chondrocytes from Peripheral Blood-derived Human Induced Pluripotent Stem Cells
Published on: July 18, 2017
Heparan sulfate proteoglycans: coordinators of multiple signaling pathways during chondrogenesis
Catherine B Kirn-Safran1, Ronald R Gomes, Anissa J Brown
1Department of Biological Sciences, University of Delaware, Newark, Delaware, USA. ckirn@udel.edu
Abstract:
Heparan sulfate proteoglycans are abundantly expressed in the pericellular matrix of both developing and mature cartilage. Increasing evidence indicates that the action of numerous chondroregulatory molecules depends on these proteoglycans. This review summarizes the current understanding of the interactions of heparan sulfate chains of cartilage proteoglycans with both soluble and nonsoluble ligands during the process of chondrogenesis. In addition, the consequences of mutating genes encoding heparan sulfate biosynthetic enzymes or heparan sulfate proteoglycan core proteins on cartilage development are discussed.
Related Concept Videos
Matrix Proteoglycans and Glycoproteins
Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Hedgehog Signaling Pathway
Hedgehog Signaling Pathway
Proteoglycans
