Related Experiment Video
Updated: Aug 25, 2026

A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
From road rash to top allergen in a flash: bacitracin
Sharon E Jacob1, William D James
1Department of Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida.
Background:
Bacitracin is an antibiotic that is produced by Bacillus subtilis, which is used in several types of consumer products, including cosmetics and ophthalmic and cutaneous ointments.
Objective:
To call attention to the rising allergic contact dermatitis associated with bacitracin.
Results:
Mass usage has resulted in an increasing number of clinically relevant allergic contact dermatitis reactions and near fatal anaphylaxis. The North American Contact Dermatitis Group has recorded its emergence as a leading allergen and continues to monitor the ever-growing allergic reaction rates.
Conclusion:
The clinical impact, scientific evidence, and need for medical cost containment all advocate the discontinuation of routine usage of bacitracin in clean surgical wounds.
Related Concept Videos
Inhalation Anthrax
Allergic Reactions
Staphylococcal Skin Infections
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Acne Infection
Cross-reactivity
