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Related Experiment Videos

Intravenous esomeprazole.

Gillian M Keating1, David P Figgitt

  • 1Adis International Limited, Mairangi Bay, Auckland, New Zealand. demail@adis.co.nz

Drugs
|April 3, 2004
PubMed
Summary
This summary is machine-generated.

Intravenous esomeprazole offers effective gastric acid control comparable to oral forms and superior to other proton pump inhibitors. This formulation is well-tolerated and beneficial for patients unable to take oral medications.

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Area of Science:

  • Gastroenterology
  • Pharmacology

Background:

  • Esomeprazole, the S-isomer of omeprazole, is a proton pump inhibitor.
  • An intravenous (IV) formulation has been developed for patients unable to take oral medications.

Purpose of the Study:

  • To evaluate the efficacy and tolerability of intravenous esomeprazole for gastric acid control.
  • To compare IV esomeprazole with oral esomeprazole, IV pantoprazole, and IV omeprazole.

Main Methods:

  • Studies in healthy volunteers compared IV and oral esomeprazole (20 or 40 mg daily for 5 days).
  • Comparisons were made between IV esomeprazole and IV pantoprazole or IV omeprazole.
  • A study in patients with erosive esophagitis (n=246) assessed healing rates with IV/oral esomeprazole (40 mg daily).

Main Results:

Related Experiment Videos

  • IV and oral esomeprazole demonstrated similar gastric acid control.
  • IV esomeprazole provided faster and more effective acid control than IV pantoprazole.
  • IV esomeprazole showed better acid suppression than IV omeprazole.
  • Approximately 80% healing rate at 4 weeks was observed in patients with erosive esophagitis treated with IV/oral esomeprazole.

Conclusions:

  • Intravenous esomeprazole provides effective gastric acid control comparable to oral administration.
  • The IV formulation is well-tolerated and offers advantages for patients requiring parenteral therapy.
  • IV esomeprazole demonstrates superior efficacy over IV pantoprazole and omeprazole in acid suppression.