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Rescue of interferon induced bone marrow aplasia in a patient with chronic myeloid leukemia by allogeneic bone marrow

A Alabdulaaly1, J Rifkind, H Solow

  • 1Princess Margaret Hospital, University Health Network, University of Toronto, 610 University Avenue, Toronto, Ont, Canada, M5G 2M9.

Leukemia & Lymphoma
|April 6, 2004
PubMed

A patient with chronic phase Philadelphia chromosome positive CML, developed severe protracted bone marrow hypoplasia after interferon therapy. This complication did not respond to two courses of immunosuppressive therapy with anti-thymocyte globulin, cyclosporin A and prednisone. The patient continued to be transfusion dependent with persistence of Philadelphia chromosome. Allogeneic BMT restored normal hematopoeisis.

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