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Related Experiment Videos

Antioxidants in patients with hyperthyroidism.

Ljiljana Mayer1, Zeljko Romić, Franjo Skreb

  • 1Department of Laboratory Medicine, Dubrava University Hospital, Zagreb, Croatia. lmayer@kbd.hr

Clinical Chemistry and Laboratory Medicine
|April 6, 2004
PubMed
Summary

Hyperthyroidism disrupts antioxidant balance, increasing oxidative stress. Therapy may normalize some antioxidant factors, suggesting treatment influences disease severity.

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Area of Science:

  • Biochemistry
  • Endocrinology
  • Oxidative Stress Research

Background:

  • Hyperthyroidism is a hypermetabolic state.
  • It involves increased oxygen utilization and reactive oxygen species (ROS) production.
  • This leads to measurable changes in antioxidative factors.

Purpose of the Study:

  • To investigate the balance of antioxidative factors in women with hyperthyroidism.
  • To compare antioxidant status in newly diagnosed Graves' disease and hyperthyroid patients on methimazole therapy versus healthy controls.
  • To explore the role of oxidative stress in hyperthyroidism.

Main Methods:

  • Measured whole blood glutathione peroxidase (GPx) and erythrocyte superoxide dismutase (SOD) activities.
  • Assessed total antioxidant status (TAS) in serum and erythrocytes.

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  • Determined serum urate and transferrin concentrations in 70 women (14 with Graves' disease, 28 on methimazole, 28 controls).

    • Main Results:

    • GPx activity was significantly decreased in all patient groups compared to controls.
    • SOD activity was decreased in newly diagnosed patients (Graves' disease) but increased in patients on therapy.
    • Serum TAS was decreased in Graves' disease patients, and erythrocyte TAS was decreased in all patient groups.

    Conclusions:

    • Impaired antioxidative factor balance contributes to oxidative stress in hyperthyroidism.
    • The observed alterations in antioxidant factors appear to be influenced by therapeutic interventions.
    • Therapy may modulate the severity of oxidative stress in hyperthyroid patients.