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The Rabbit Model of Accelerated Atherosclerosis: A Methodological Perspective of the Iliac Artery Balloon Injury
Published on: October 3, 2017
[Effects of dry red wine on experimental atherosclerosis in rabbits]
1Department of Cardiology, Xingqiao Hospital, the Third Milltary Medical University, Chongqing 400037, China.
Objective:
To study the effects of dry red wine in the different stages of experimental atherosclerosis (AS) at the cell, molecular and gene regulation levels in order to provide scientific basis for using dry red wine in the prevention of atherosclerosis.
Methods:
Blood vessel wall pathological changes, activity of NF-kB and the expressions of monocyte chemotactic protein-1 (MCP-1) and protein kinase C (PKC alpha) were observed in dietary induced atherosclerosis rabbit model by morphology study, electrophoretic mobility shift assay (EMSA), and in situ hybridyzation, and the effects of dry red wine intervention were examined.
Results:
Dry red wine significantly suppressed the proliferation of atherosclerosis intima and NF-kappaB activation (4w: 18.5 +/- 0.6 vs 13.7 +/- 0.3; 8w: 26 +/- 0.9 vs 17.8 +/- 0.5; 12w: 39.9 +/- 1.2 vs 27.8 +/- 0.8), and down-regulated the expressions of MCP-1 and PKC alpha.
Conclusions:
The results confirmed that dry red wine could protect AS tissues and prolong its development by suppressing NF-kappaB activation, down-regulating the expressions of MCP-1 and PKC alpha, which may take part in pathogenesis of AS.
Insights
Dry red wine effectively combats atherosclerosis by suppressing NF-kappaB activation and reducing key inflammatory markers. This study provides a scientific basis for red wine
Area of Science:
- Cardiovascular Research
- Molecular Biology
- Nutraceutical Science
Background:
- Atherosclerosis (AS) is a chronic inflammatory disease.
- Understanding molecular mechanisms is crucial for prevention.
- Dietary interventions show promise in managing AS.
Purpose of the Study:
- To investigate the impact of dry red wine on experimental atherosclerosis.
- To analyze effects at cellular, molecular, and gene regulation levels.
- To establish a scientific foundation for red wine's role in AS prevention.
Main Methods:
- Utilized a dietary-induced atherosclerosis rabbit model.
- Assessed pathological changes via morphology studies.
- Measured NF-kappaB activation, MCP-1, and PKC alpha expression using EMSA and in situ hybridization.
Main Results:
- Dry red wine significantly inhibited intima proliferation and NF-kappaB activation.
- Down-regulated the expression of monocyte chemotactic protein-1 (MCP-1) and protein kinase C alpha (PKC alpha).
- Observed protective effects on AS tissues and delayed disease progression.
Conclusions:
- Dry red wine demonstrates protective effects against atherosclerosis.
- Suppression of NF-kappaB activation and down-regulation of MCP-1 and PKC alpha contribute to AS pathogenesis.
- Findings support dry red wine's potential in AS prevention and management.
