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Related Experiment Videos

Drug-induced headache.

William B Young1

  • 1Department of Neurology, Thomas Jefferson University Hospital, Jefferson Headache Center, 111 South Eleventh Street, Gibbon Building, Suite 8130, Philadelphia, PA 19107, USA. william.b.young@jefferson.edu

Neurologic Clinics
|April 6, 2004
PubMed
Summary
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Medication overuse headache is complex, involving physical and psychological factors. Treatment can involve outpatient, inpatient, or infusion center options, with specific drug classes like NO donors and PDE inhibitors inducing distinct headache patterns.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Medication overuse headache (MOH) is a prevalent and intricate neurological disorder.
  • It presents with both physical and psychological components, complicating treatment approaches.

Purpose of the Study:

  • To outline treatment strategies for medication overuse headache.
  • To differentiate the headache induction patterns of common drug classes.

Main Methods:

  • Review of treatment settings including outpatient, inpatient, and day treatment with intravenous medication.
  • Analysis of headache induction by nitric oxide (NO) donors and phosphodiesterase (PDE) inhibitors.

Main Results:

  • Treatment for MOH can occur in various settings, including specialized infusion centers.

Related Experiment Videos

  • Nitric oxide donors (e.g., nitroglycerin) induce a biphasic headache in migraineurs.
  • PDE inhibitors (e.g., sildenafil) induce a monophasic headache.

    • Conclusions:

    • Effective management of medication overuse headache requires tailored approaches based on patient needs.
    • Understanding the specific headache-inducing mechanisms of different drug classes is crucial for treatment.
    • NO donors and PDE inhibitors represent key pharmacological classes implicated in acute headache induction.