Transforming growth factor-beta1 (TGF-beta1) in plasma is associated with preeclampsia risk in Peruvian women with
Martin Muy-Rivera1, Sixto E Sanchez, Surab Vadachkoria
1Center for Perinatal Studies, Swedish Medical Center, Seattle, Washington 98122, USA. Martin.Muy@Swedish.org
Background:
In a case-control study of 100 preeclamptics and 100 controls, we assessed plasma transforming growth factor-beta1 (TGF-beta1) concentrations in relation to preeclampsia risk among Peruvian women with and without systemic inflammation.
Methods:
Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Results:
The OR of preeclampsia increased across quartiles of TGF-beta1 concentrations. Women with elevated TGF-beta1 and a proinflammatory profile experienced the highest risk of preeclampsia (OR = 15.4, 95% CI 4.7-50.4).
Conclusions:
Our results confirm an association between TGF-beta1 and risk of preeclampsia and extend the literature by indicating a strong association in women with systemic inflammation.
