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Related Concept Videos

Correlations02:20

Correlations

Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
Coefficient of Correlation01:12

Coefficient of Correlation

The correlation coefficient, r, developed by Karl Pearson in the early 1900s, is numerical and provides a measure of strength and direction of the linear association between the independent variable x and the dependent variable y.
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the strength of the linear...
Prediction Intervals01:03

Prediction Intervals

The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
The...
Bioavailability Study Design: Absolute Versus Relative Bioavailability01:27

Bioavailability Study Design: Absolute Versus Relative Bioavailability

Bioavailability is a crucial pharmacokinetic parameter that quantifies the proportion of an administered drug that reaches the systemic circulation and is available for therapeutic action. Regulatory agencies mandate the assessment of bioavailability, typically measured as the area under the drug plasma concentration-versus-time curve (AUC), to ensure the efficacy and safety of pharmaceutical products. These evaluations are categorized as absolute and relative bioavailability studies.Absolute...
Measurement of Bioavailability: Pharmacodynamic Methods01:20

Measurement of Bioavailability: Pharmacodynamic Methods

Pharmacodynamic methods provide insights into a drug's effects on physiological processes over time and play a crucial role in understanding bioavailability and therapeutic efficacy. These methods can be broadly classified into acute pharmacological and therapeutic response approaches, each with distinct mechanisms and applications.The acute pharmacological response method directly correlates a drug's physiological effects, such as ECG or pupil diameter changes, to its time course in the body.
Drug Product Performance: In Vitro–In Vivo Correlation01:20

Drug Product Performance: In Vitro–In Vivo Correlation

In pharmaceutical development, it's crucial to establish a predictive in vitro–in vivo correlation (IVIVC) for two or more formulations to gain a comprehensive understanding of release properties. IVIVC reduces the need for costly in vivo studies and facilitates the establishment of meaningful dissolution specifications with significant cost savings and decreased regulatory burden. Furthermore, a meaningful IVIVC should predict Cmax and AUC within 20%, aligning with FDA guidance while adhering...

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Related Experiment Video

Updated: Jul 9, 2026

'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake
04:46

'Boden Food Plate': Novel Interactive Web-based Method for the Assessment of Dietary Intake

Published on: September 18, 2018

Correlations between estimated and true dietary intakes.

Gary E Fraser1, David J Shavlik

  • 1Center for Health Research, School of Public Health, Loma Linda University, Loma Linda, CA 92350, USA. gfraser@sph.llu.edu

Annals of Epidemiology
|April 7, 2004
PubMed
Summary

This study introduces a new method to estimate correlations between dietary assessment tools and true intake. Results show reference methods generally correlate better with true intake than questionnaires, highlighting potential issues with regression calibration.

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Area of Science:

  • Nutritional epidemiology
  • Biostatistics
  • Dietary assessment methodology

Background:

  • Accurate dietary intake assessment is crucial for nutritional research.
  • Current dietary assessment methods, like food frequency questionnaires and reference methods, have limitations in correlating with true intake.
  • The validity of these methods is often difficult to quantify due to complex error structures.

Purpose of the Study:

  • To develop and describe a statistical method for estimating correlations between dietary assessment tools and true dietary intake.
  • To assess the relative validity of food frequency questionnaires versus reference methods.
  • To investigate the correlation between errors in questionnaire and reference dietary data.

Main Methods:

  • Developed an error model incorporating data from a food frequency questionnaire (Q), a reference method (R), and a biological marker (M).
  • The model allows for non-classical error structures for R and M, and does not assume zero correlation between errors in Q and R.
  • Credible intervals were calculated for correlations between R, Q, M, true dietary data (T), and errors in R and Q.

Main Results:

  • Applied the model to a validation dataset, finding correlations between dietary data and true intake generally ranged from 0.4 to 0.8.
  • Correlations between the reference method and true intake (R,T) typically exceeded those of the questionnaire and true intake (Q,T), suggesting higher validity for R.
  • Estimated correlations between errors in R and Q were frequently non-zero, indicating potential problems with regression calibration using imperfect reference data.

Conclusions:

  • Integrating a biological marker with dietary data enables the calculation of correlations between estimated and true dietary intakes under reasonable error assumptions.
  • Sensitivity analyses are recommended for individual variables within the model.
  • The findings underscore the importance of estimating error correlations for accurate dietary assessment validation.