Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adaptable adaptors for coated vesicles.

Margaret S Robinson1

  • 1University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Hills Road, Cambridge, UK CB2 2XY. msr12@mole.bio.cam.ac.uk

Trends in Cell Biology
|April 7, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of the AP-1 adaptor complex in outgoing and incoming membrane traffic.

The Journal of cell biology·2024
Same author

Stable endocytic structures navigate the complex pellicle of apicomplexan parasites.

Nature communications·2023
Same author

Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complex.

The Journal of cell biology·2021
Same author

Adaptor protein complexes and disease at a glance.

Journal of cell science·2019
Same author

Fast and cloning-free CRISPR/Cas9-mediated genomic editing in mammalian cells.

Traffic (Copenhagen, Denmark)·2019
Same author

AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A.

Nature communications·2018
Same journal

Horizontal transfer of mitochondria in cancer: The physiology reborn in disease?

Trends in cell biology·2026
Same journal

Spindle errors: A stress test for epithelial robustness.

Trends in cell biology·2026
Same journal

Multicellular ecosystems: Linking cellular diversity to tissue function and disease.

Trends in cell biology·2026
Same journal

Orchestrating the signaling-bias at the protease-activated receptor, PAR1.

Trends in cell biology·2026
Same journal

Crashing by design: Utilizing DNA damage for MCC differentiation.

Trends in cell biology·2026
Same journal

The value of a shared lab: Our insights.

Trends in cell biology·2026
See all related articles

Cellular adaptors are key proteins that sort cargo into vesicles for transport. New research reveals a diverse family of adaptors, including AP complexes and GGAs, crucial for cellular organization and development.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Adaptor proteins are essential for intracellular trafficking, mediating cargo selection into coated vesicles.
  • Initially, only AP-1 and AP-2 adaptor complexes were known, but the landscape has expanded significantly.

Purpose of the Study:

  • To elucidate the expanding diversity and function of adaptor proteins in cellular transport pathways.
  • To highlight the role of phosphoinositides in adaptor targeting and network formation.
  • To underscore the involvement of adaptors in both general and specialized cellular processes, including development.

Main Methods:

  • The abstract does not specify methods, focusing on a review of existing knowledge and emerging concepts.

Main Results:

Related Experiment Videos

  • The discovery of additional adaptor complexes (AP-3, AP-4) and monomeric adaptors (GGAs) expands the known repertoire beyond AP-1 and AP-2.
  • Adaptor proteins are recruited to membranes via phosphoinositide interactions.
  • Adaptors form networks to co-package diverse cargo into single vesicles.
  • Adaptors play roles in fundamental cellular trafficking and specialized functions like organelle biogenesis and developmental cell fate determination.

Conclusions:

  • The adaptor protein family is more diverse than previously understood, with distinct complexes and monomeric forms.
  • Phosphoinositide binding is a critical mechanism for adaptor localization.
  • Adaptor networks enable efficient and specific cargo sorting for various cellular destinations.
  • Adaptor proteins are fundamental regulators of cellular organization, function, and development.