Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dimensional changes of compacts after compression.

P York, E D Baily

    The Journal of Pharmacy and Pharmacology
    |February 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interaction Phenomena in some Aqueous-Based Tablet Coating Polymer Systems.

    Pharmaceutical research·2013
    Same author

    Insula and orbitofrontal cortical morphology in substance dependence is modulated by sex.

    AJNR. American journal of neuroradiology·2012
    Same author

    Modelling formulations using gene expression programming--a comparative analysis with artificial neural networks.

    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2011
    Same author

    Effect of crystallisation conditions and feedstock morphology on the aerosolization performance of micronised salbutamol sulphate.

    International journal of pharmaceutics·2011
    Same author

    Comminution of ibuprofen to produce nano-particles for rapid dissolution.

    International journal of pharmaceutics·2011
    Same author

    The impact of material attributes and process parameters on the micronisation of lactose monohydrate.

    International journal of pharmaceutics·2011
    Same journal

    Phytochemical constituents, biological activities, toxicological profiles, and current applications of Muntingia calabura L.: an updated review.

    The Journal of pharmacy and pharmacology·2026
    Same journal

    Uterine relaxant effects of Ageratum conyzoides essential oil: influence of hormonal status and calcium modulation.

    The Journal of pharmacy and pharmacology·2026
    Same journal

    Liraglutide-mediated protection against ethanol-induced gastric ulcer in male and female rats: enhancement of mucosal defense, anti-inflammatory and antioxidant mechanism.

    The Journal of pharmacy and pharmacology·2026
    Same journal

    Exploring the mechanism of action of Qufengzhitong pills in treating rheumatoid arthritis via the PI3K/AKT, NF-κB, and MAPK pathways.

    The Journal of pharmacy and pharmacology·2026
    Same journal

    Mechanistic evidence for PI3K/Akt-driven reactivation of Nrf2/HO-1 by dapagliflozin in acute cisplatin hepatotoxicity.

    The Journal of pharmacy and pharmacology·2026
    Same journal

    Advances in nano-drug delivery systems for targeting therapy of breast cancer.

    The Journal of pharmacy and pharmacology·2026
    See all related articles

    Non-contact optical methods revealed significant dimensional changes in methylcellulose compacts. Granulating lactose with maize starch improved compression force distribution, reducing strain recovery ratios.

    Area of Science:

    • Materials Science
    • Pharmaceutical Technology
    • Powder Compaction

    Background:

    • Understanding powder compaction behavior is crucial for pharmaceutical manufacturing.
    • Material properties significantly influence tablet dimensions and mechanical integrity.
    • Spray-dried lactose and methylcellulose are common pharmaceutical excipients.

    Purpose of the Study:

    • To measure dimensional changes in compacts of various pharmaceutical materials using a non-contact optical technique.
    • To investigate the impact of material properties on axial and radial expansion during compaction.
    • To evaluate the effect of granulation with maize starch on the compaction behavior of spray-dried lactose.

    Main Methods:

    • Utilized a non-contact optical technique to measure compact height and diameter.

    Related Experiment Videos

  • Prepared compacts from sodium chloride, spray-dried lactose, methylcellulose powders, and lactose-maize starch granulations.
  • Analyzed axial and radial strain recovery ratios.

    • Main Results:

    • Sodium chloride and spray-dried lactose showed minimal dimensional changes.
    • Methylcellulose powders exhibited substantial axial expansion (up to 30%) and minor radial expansion (3%).
    • Lactose-maize starch granulation reduced the axial to radial strain recovery ratio from 5-9:1 to approximately 1:1.

    Conclusions:

    • Material-specific properties dictate compaction behavior and dimensional stability.
    • Methylcellulose's inherent characteristics lead to significant expansion upon compression.
    • Maize starch granulation enhances force distribution in lactose compacts, improving compression characteristics.