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[Hematological values in fetal blood by cordocentesis]
J Murotsuki1, K Okamura, M Iwamoto
1Department of Obstetrics and Gynecology, Tohoku University School of Medicine, Sendai.
Nihon Sanka Fujinka Gakkai Zasshi
|June 1, 1992
Summary
Established reference ranges for fetal blood parameters like hemoglobin and hematocrit from 72 pregnancies. These ranges aid in diagnosing fetal anemia and guiding therapeutic decisions.
Area of Science:
- Obstetrics and Gynecology
- Fetal Medicine
- Hematology
Context:
- Establishing accurate reference ranges for fetal hematological parameters is crucial for diagnosing and managing various pregnancy complications.
- Cordocentesis provides direct access to fetal blood for precise hematological analysis.
Purpose:
- To establish reference ranges for fetal hemoglobin, hematocrit, white blood cell, and platelet counts across different gestational ages (16-39 weeks).
- To investigate correlations between these hematological parameters and gestational age.
- To identify the incidence and potential causes of fetal anemia.
Summary:
- Reference ranges were determined from 72 normal or selectively malformed fetuses via cordocentesis.
- Significant positive correlations were found between hemoglobin, hematocrit, platelet counts, and gestational age.
- Fetal anemia was identified in 7% of cases, with higher prevalence in hydropic fetuses, and was linked to conditions like hydrops fetalis and Rh isoimmunization.
Impact:
- Provides essential data for the diagnosis of fetal hematological disorders.
- Supports clinical decision-making for fetal therapy, particularly in cases of anemia.
- Highlights the prognostic significance of gestational age and anemia severity in affected fetuses.