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Gentamicin pharmacokinetics in term newborn infants receiving high-frequency oscillatory ventilation or conventional

Caraciolo J Fernandes, Donough J O'Donovan, Ngoc-Yen T Nguyen

    Journal of Perinatology : Official Journal of the California Perinatal Association
    |April 7, 2004
    PubMed
    Abstract

    No abstract available in PubMed .

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    Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...

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