Related Experiment Video
Updated: Aug 25, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Published on: January 31, 2025
Hypotrichosis and nail dysplasia: a novel hidrotic ectodermal dysplasia
Shannon Harrison1, Rodney Sinclair
1Department of Medicine (Dermatology), St Vincent's Hospital, Fitzroy, Melbourne, Victoria 5065, Australia.
Abstract:
We report a unique isolated hair and nail ectodermal dysplasia in a 3-year-old girl. Clinical examination revealed short, sparse scalp hair, absent eyebrows, short eyelashes and nail dystrophy in all digits. Nail changes included shortened nail plate with distal onycholysis and loss of the cuticle. Sweating and teeth were normal. Development was normal. Scanning electron microscopy of the hair only demonstrated trichorrhexis nodosa. There was no pili torti. Vertically sectioned scalp biopsy revealed hypoplastic hair follicles and a horizontally sectioned biopsy showed a decrease in the overall number of hair follicles present. Treatment with topical minoxidil 5% 1 mL twice each day massaged into the scalp led to only minimal improvement and was discontinued after 12 months.
More Related Videos
Related Concept Videos
Pleiotropy
Cytoskeletal Linker Proteins - Plakins
Nondisjunction
Nondisjunction
Skin Diseases and Disorders
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Hedgehog Signaling Pathway

