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Testosterone as a modulator of vascular behavior.

Marguerite Littleton-Kearney1, Patricia D Hurn

  • 1Johns Hopkins Schools of Nursing and Medicine, 525 N. Wolfe Street, Room 460, Baltimore, MD 21205-2110, USA. mkearney@jhmi.edu

Biological Research for Nursing
|April 8, 2004
PubMed
Summary

Testosterone

Area of Science:

  • Cardiovascular Science
  • Endocrinology
  • Physiology

Background:

  • Male sex is a known risk factor for cardiovascular disease, with differing prevalence patterns between men and women.
  • Testosterone's vascular effects are complex, varying with dose, duration, and underlying conditions.
  • Physiological effects of testosterone on vascular tone are not fully understood, with evidence for both vasodilation and vasoconstriction.

Purpose of the Study:

  • To review the current understanding of testosterone's physiological effects on vascular behavior.
  • To explore testosterone's role in vascular health and disease.
  • To highlight the need for further research, particularly in women.

Main Methods:

  • Review of existing literature on testosterone's vascular effects.

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  • Analysis of data from isolated vessels, animal models, and clinical studies.
  • Focus on endothelium-dependent and independent mechanisms, including nitric oxide pathways and ion channels.

    • Main Results:

    • Pharmacological doses of testosterone/dihydrotestosterone may cause vasodilation.
    • Testosterone can alter vascular tone via endothelium-dependent (nitric oxide) and independent mechanisms.
    • Clinical data suggest potential benefits in men with coronary artery disease, but risks (hypertension, cardiovascular events) in women.

    Conclusions:

    • Testosterone's vascular actions are complex and sex-dependent.
    • More research is needed to clarify testosterone's role in vascular health and disease, especially in women.
    • The efficacy and safety of androgen therapy require further investigation.