[Clinical significance of serum S-100B protein in severe cerebral injury]
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Updated: Aug 25, 2026

Quantitative Measurement of Intrathecally Synthesized Proteins in Mice
Published on: November 29, 2019
Dian-lei Hu1, Xian-hua Liu, Xiao-liang Yu
1Department of Neurosurgery, Xuzhou Third Hospital, Xuzhou 221005, Jiangsu, China.
Objective:
To investigate the value of S-100B protein as a biology marker in diagnosis and prognostic after severe cerebral injury.
Methods:
Sixty-six patients with severe head injury (Glasgow coma scale score (GCS)
Results:
Of 66 patients, 25 patients died, mutilation in 22 patients, 19 patients had a good outcome. Patients who died had significantly higher serum S-100B values compared with those who survived (median 2.60 microg/L vs. 0.55 microg/L, P<0.001), 14 of 25 patients who died had peak S-100B values of 2.00 microg/L or higher, compared with 4 of 41 surviving patients (P<0.005).
Conclusion:
S-100B protein has a reliable value in diagnosis and prognostic after severe head injury.
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