Related Experiment Video

Updated: Aug 24, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Lipoprotein (a) in coronary artery disease in Indian population

V Govindaraju1, Neelam, C N Manjunath

  • 1Sri Jayadeva Institute of Cardiology, Bangalore 560069.

Journal of the Indian Medical Association
|April 10, 2004
PubMed

Insights

Lipoprotein(a) levels do not significantly correlate with coronary artery disease (CAD) in Indian patients. This study found no significant difference in lipoprotein(a) between CAD patients and controls, suggesting it

Area of Science:

  • Cardiology
  • Biochemistry
  • Epidemiology

Background:

  • Coronary artery disease (CAD) prevalence is rising in India, with traditional risk factors inadequately explaining the incidence.
  • Lipoprotein(a) is a known risk factor for atherosclerosis, but data specific to the Indian population is limited.
  • Limited understanding of novel risk factors like lipoprotein(a) hinders effective CAD prevention strategies in India.

Purpose of the Study:

  • To investigate the association between lipoprotein(a) levels and the presence of coronary artery disease (CAD) in Indian patients.
  • To determine if lipoprotein(a) serves as a significant risk factor for CAD in the Indian demographic.
  • To explore the role of lipoprotein(a) in specific subgroups, including diabetics and patients with myocardial infarction.

Main Methods:

  • A case-control study involving 300 patients with diagnosed CAD and 200 healthy controls.
  • Assessment of clinical profiles, lipid profiles, coronary angiography, and plasma lipoprotein(a) levels.
  • Statistical analysis to compare lipoprotein(a) levels between CAD patients and controls, and within subgroups.

Main Results:

  • No significant difference was observed in mean plasma lipoprotein(a) levels between the CAD group (32.18 +/- 1.37 mg/dl) and the control group (29.94 +/- 2.59 mg/dl).
  • Conventional risk factors such as diabetes, hypertension, smoking, and family history did not differ significantly between groups.
  • A trend towards increased lipoprotein(a) levels in diabetic patients and those with myocardial infarction was noted but lacked statistical significance. No correlation found with the number of stenosed coronary arteries.

Conclusions:

  • Plasma lipoprotein(a) levels do not show a significant correlation with the presence of coronary artery disease in the studied Indian population.
  • Lipoprotein(a) may not be a primary independent risk factor for CAD in this demographic, unlike in other populations.
  • Further research is needed to explore other potential risk factors contributing to the high CAD burden in India.

Related Concept Videos

Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...