Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Poisoning with amitraz.

Alex T Proudfoot1

  • 1National Poisons Information Service (Birmingham Centre), City Hospital, Birmingham, UK.

Toxicological Reviews
|April 10, 2004
PubMed
Summary
This summary is machine-generated.

Amitraz poisoning, primarily in children, has increased recently. While amitraz (an insecticide) causes specific toxic effects like impaired consciousness and respiratory depression, its toxicity is hard to separate from solvents. Most patients recover with intensive care.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical toxicology in Edinburgh, two centuries of progress.

Clinical toxicology (Philadelphia, Pa.)·2013
Same author

Aluminium and zinc phosphide poisoning.

Clinical toxicology (Philadelphia, Pa.)·2009
Same author

Sodium fluoroacetate poisoning.

Toxicological reviews·2007
Same author

Anticoagulant rodenticides.

Toxicological reviews·2006
Same author

Poisoning due to urea herbicides.

Toxicological reviews·2006
Same author

Poisoning due to pyrethroids.

Toxicological reviews·2005
Same journal

The role of oximes in the treatment of nerve agent poisoning in civilian casualties.

Toxicological reviews·2007
Same journal

A critical reconsideration of the clinical effects and treatment recommendations for sodium channel blocking drug cardiotoxicity.

Toxicological reviews·2007
Same journal

Therapeutic drug monitoring of digoxin: impact of endogenous and exogenous digoxin-like immunoreactive substances.

Toxicological reviews·2007
Same journal

Diacetyl-induced lung disease.

Toxicological reviews·2007
Same journal

Nanotechnology and nanotoxicology: a primer for clinicians.

Toxicological reviews·2007
Same journal

Development of the bisquaternary oxime HI-6 toward clinical use in the treatment of organophosphate nerve agent poisoning.

Toxicological reviews·2007
See all related articles

Area of Science:

  • Veterinary Toxicology
  • Clinical Toxicology
  • Pharmacology

Background:

  • Amitraz, an insecticide and veterinary medicine, has been available globally since 1974.
  • Recent years have seen a rise in reported amitraz poisoning cases, predominantly affecting children in Turkey.
  • Distinguishing amitraz toxicity from its hydrocarbon solvent carriers remains challenging.

Purpose of the Study:

  • To review the clinical features and outcomes of amitraz poisoning.
  • To understand the toxicological mechanism of amitraz.
  • To explore potential antidotes for amitraz toxicity.

Main Methods:

  • Review of human poisoning cases and animal studies.
  • Analysis of clinical manifestations and treatment outcomes.

Related Experiment Videos

  • Examination of pharmacological actions, specifically alpha 2-adrenoceptor stimulation.

    • Main Results:

    • Amitraz poisoning presents with central nervous system depression, respiratory depression, bradycardia, hypotension, hypothermia, and hypoglycemia.
    • The majority of human cases involve children and occur in Turkey.
    • Intensive care is effective, with only one suspected fatality documented.
    • Animal studies suggest alpha 2-adrenoceptor antagonists (yohimbine, atipamezole) may reverse toxicity.

    Conclusions:

    • Amitraz toxicity is characterized by alpha 2-adrenoceptor agonism.
    • Most human amitraz poisoning cases are severe but survivable with intensive care.
    • Alpha 2-adrenoceptor antagonists show promise as antidotes but require human clinical trials.