[Experimental increase in resistance of the osteoporotic distal radius with a calcium phosphate cement]

Diagnosis and treatment of osteoporosis are focused on demineralisation but bone mineral density is not directly correlated with bone strength. As with every material, the mechanical strength of bone depends upon its Young's modulus and its cross-sectional moment of inertia. In the clinical situation, bone strength can be quantified using peripheral quantitative computed tomography imaging (pQCT), a non-invasive imaging method, which allows calculation of a strength index. In this study, we tried to increase the fracture threshold of the distal radius by directly increasing bone strength rather than density. Twenty wrists in 10 cadavers were filled percutaneously with a calcium phosphate cement. Fluoroscopy and pQCT were performed twice, once before cementing and again 24 h after cement crystallisation to hydroxyapatite. We obtained measurements of trabecular and total bone density, and also stress strain index (SSI). Our results showed that trabecular bone density increased by a factor of 2.85, whereas total bone density increased by 1.61 and SSI by 1.99. Fluoroscopy showed two small leaks of cement at the point of injection. This study demonstrated that percutaneous injection of calcium phosphate cement increased distal radius strength, and consequently its fracture threshold. This technique could be employed in the future to prevent the occurrence of fractures in osteoporotic patients.