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Related Experiment Videos

CT attenuation correction for myocardial perfusion quantification using a PET/CT hybrid scanner.

Pascal Koepfli1, Thomas F Hany, Christophe A Wyss

  • 1Nuclear Cardiology, Cardiovascular Center, University Hospital Zurich, Zurich, Switzerland.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|April 10, 2004
PubMed
Summary

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Using computed tomography (CT) for attenuation correction (AC) in positron emission tomography (PET) significantly shortens scan times. CT AC provides accurate myocardial blood flow (MBF) assessment in hybrid PET/CT imaging.

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Cardiovascular Imaging

Background:

  • Positron Emission Tomography (PET) commonly uses a 10- to 20-minute transmission scan with a rotating Germanium-68 ((68)Ge) source for attenuation correction (AC).
  • This AC procedure is time-consuming and can be expedited by utilizing rapid CT scans on hybrid PET/CT scanners.

Purpose of the Study:

  • To evaluate the feasibility and accuracy of CT-based attenuation correction (AC) for quantitative myocardial perfusion PET imaging.

Main Methods:

  • Myocardial blood flow (MBF) was measured using Nitrogen-13 ((13)N)-labeled ammonia and PET at rest and during adenosine stress.
  • CT scans (0.5 seconds) with varying tube currents were compared to standard (68)Ge transmission scans for AC.
  • Reconstruction methods (filtered backprojection and iterative reconstruction) were also compared.

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Main Results:

  • No significant difference in MBF was observed when using CT AC versus (68)Ge AC across different CT tube currents.
  • (13)N-NH(3) PET with CT AC demonstrated high repeatability, with coefficients of variance from 2% to 6% at rest and stress.
  • CT AC yielded better reproducibility coefficients compared to (68)Ge AC when using the same reconstruction algorithm.

Conclusions:

  • CT-based attenuation correction (AC) is a feasible and accurate method for quantitative myocardial perfusion PET imaging on hybrid PET/CT scanners.
  • Utilizing CT AC, particularly at a tube current of 10 mA, significantly reduces scan time without compromising the accuracy of MBF assessment.