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Pulmonary function tests and thyroid hormone concentrations in patients with chronic obstructive pulmonary disease
Oguzhan Okutan1, Zafer Kartaloglu, Mehmet Emin Onde
1Department of Pulmonary Diseases, GATA Haydarpasa Training Hospital, Istanbul, Turkey. oguzhanokutan@hotmail.com
Summary
Pulmonary function and blood gas levels in chronic obstructive pulmonary disease (COPD) patients are linked to free triiodothyronine (fT3) levels. Increased respiratory workload may impact thyroid function in COPD.
Area of Science:
- Pulmonary Medicine
- Endocrinology
Background:
- Chronic obstructive pulmonary disease (COPD) is a significant respiratory illness.
- Thyroid function plays a role in overall metabolic and physiological processes.
- The interplay between respiratory compromise and thyroid status in COPD requires further investigation.
Purpose of the Study:
- To investigate the relationship between pulmonary function tests (PFTs), arterial blood gases (ABGs), and thyroid gland function in patients with COPD.
- To compare these parameters between COPD patients and healthy controls.
Main Methods:
- A cohort of 32 stable COPD patients and 15 healthy controls were enrolled.
- Comprehensive assessments included PFTs, ABGs, thyroid hormone concentrations (TSH, fT4, fT3), thyroid ultrasonography, and scintigraphy.
Main Results:
- COPD patients exhibited lower PFT values (VC, FVC, FEV1, PEF) and PaO2 compared to controls.
- Higher PaCO2 and free triiodothyronine (fT3) levels were observed in COPD patients, though all thyroid hormone concentrations remained within normal limits.
- A positive association was found between PaCO2 and fT3; other parameters showed negative associations with fT3.
Conclusions:
- Pulmonary and arterial blood gas alterations in COPD patients appear correlated with fT3 concentrations.
- Elevated respiratory workload in COPD may influence thyroid function, particularly fT3 levels.