Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug use and acute leukemia.

G Traversa1, F Menniti-Ippolito, R Da Cas

  • 1Department of Epidemiology and Biostatistics, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

Pharmacoepidemiology and Drug Safety
|April 10, 2004
PubMed
Summary

This case-control study investigated drug use and acute leukemia in Rome. While some drug categories showed increased odds, no statistically significant causal links to leukemia were found.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early clearance of hairy cell leukaemia in the bone marrow after first-line treatment with cladribine predicts a favourable outcome.

British journal of haematology·2023
Same author

Short-Term Memory Deficit Associates with miR-153-3p Upregulation in the Hippocampus of Middle-Aged Mice.

Molecular neurobiology·2023
Same author

Achieving the Cure of Follicular Lymphoma: is it Time to Finalize Treatment Strategies to Reach This Goal in a Subset of Patients?

Mediterranean journal of hematology and infectious diseases·2023
Same author

Daratumumab plus bortezomib or daratumumab plus lenalidomide as salvage therapy for patients with myeloma: initial follow-up of an Italian multicentre retrospective clinical experience by 'Rete Ematologica Pugliese'.

Annals of hematology·2022
Same author

Knowledge, attitude, barriers, professional behaviour and possible interventions: a survey on healthcare-associated infections among the healthcare workers of an intensive care unit in a large teaching hospital in Rome.

Annali di igiene : medicina preventiva e di comunita·2021
Same author

Offline ventral subiculum-ventral striatum serial communication is required for spatial memory consolidation.

Nature communications·2019

Area of Science:

  • Epidemiology
  • Pharmacology
  • Oncology

Background:

  • Investigating potential environmental and pharmaceutical risk factors for acute leukemia is crucial for public health.
  • Understanding drug-induced leukemia requires careful epidemiological study design.

Purpose of the Study:

  • To examine the association between preceding drug use and the occurrence of acute leukemia.
  • To identify specific drug classes that may be implicated in the etiology of acute leukemia.

Main Methods:

  • A case-control study was conducted in Rome involving 202 acute leukemia patients and 2020 matched controls.
  • Drug exposure data was retrieved from the National Health Service for the period preceding diagnosis.
  • Exposure was categorized into 'any use,' 'high use,' and 'very high use' for NSAIDs.

Related Experiment Videos

Main Results:

  • High-dose chloramphenicol use showed an odds ratio (OR) of 1.8 (95% CI: 0.6-5.3).
  • Tricyclic antidepressants (OR=1.7) and oral contraceptives (OR=1.8) had increased ORs, but not statistically significant.
  • Very high NSAID use was associated with a decreased occurrence of acute leukemia (OR=0.4).

Conclusions:

  • This study provides preliminary insights into the potential role of certain drugs in acute leukemia.
  • Further research is needed to confirm these findings and explore potential causal relationships, acknowledging study limitations.