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Updated: Aug 20, 2026

Non-invasive Parenchymal, Vascular and Metabolic High-frequency Ultrasound and Photoacoustic Rat Deep Brain Imaging
Published on: March 2, 2015
Ultrasound attenuation imaging using compound acquisition and processing
Haifeng Tu1, Tomy Varghese, Ernest L Madsen
1Department of Medical Physics, The University of Wisconsin-Madison Madison, WI 53706, USA. htu@wisc.edu
Abstract:
A method that combines both spatial and frequency compounding is described for measuring attenuation in tissue. The technique applies a reference phantom to account for imaging system dependencies of echo signals. Emphasis is given to local attenuation estimates, to reduce the variance of the attenuation measurements over small regions of interest (ROI) and to enable coarse attenuation imaging. Experiments using a uniform phantom show that the standard deviation of local attenuation estimates within a ROI drops when greater degrees of compounding are applied. Attenuation images of a specially designed phantom containing inclusions with attenuation contrast illustrate the accuracy and precision of the technique.
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