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Related Experiment Videos

Testosterone action on skeletal muscle.

Karen L Herbst1, Shalender Bhasin

  • 1UCLA School of Medicine, Charles R. Drew University, Los Angeles, California 90059, USA.

Current Opinion in Clinical Nutrition and Metabolic Care
|April 13, 2004
PubMed
Summary
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Testosterone directly builds muscle and reduces fat by influencing cell commitment to muscle growth. While effective in older men, higher doses increase adverse events, necessitating further research for functional outcomes.

Area of Science:

  • Endocrinology
  • Muscle Physiology
  • Cell Biology

Background:

  • Androgens, like testosterone, play a role in regulating body composition.
  • Understanding the direct anabolic effects of androgens on skeletal muscle is crucial for various physiological and pathological states.

Purpose of the Study:

  • To review recent data on the direct anabolic effects of androgens on mammalian skeletal muscle.
  • To examine the mechanisms by which testosterone influences body composition.

Main Methods:

  • Review of recent scientific literature and data.
  • Analysis of studies investigating testosterone's effects on lean mass, fat mass, and cellular mechanisms in muscle.

Main Results:

  • Testosterone administration increases lean body mass and decreases fat mass in men, with effects correlated to dose and concentration.

Related Experiment Videos

  • Older men show similar anabolic responsiveness to testosterone as younger men, but with a higher incidence of adverse events at higher doses.
  • Androgens appear to promote myogenic lineage commitment and inhibit adipogenesis via androgen receptor pathways, increasing muscle satellite cells and myonuclei.

    • Conclusions:

    • Testosterone promotes skeletal muscle hypertrophy through mechanisms including the modulation of pluripotent mesenchymal cell commitment.
    • Observed improvements in muscle strength and leg power warrant further investigation into testosterone's effects on physical function and health outcomes in aging and chronic illness-related sarcopenia.