Internet based multi-institutional clinical research: a convenient and secure option

Area of Science:

• Clinical Research Informatics
• Medical Informatics
• Health Services Research

Background:

• Multi-institutional, prospective, randomized trials are crucial in modern clinical research.
• Remote participation in trials can be challenging due to lengthy data submission processes.
• Internet-based systems offer a potential solution for efficient multi-institutional trial management.

Purpose of the Study:

• To evaluate the feasibility and efficiency of an Internet-based system for a multi-institutional, prospective, randomized trial.
• To assess investigator ease of use and perceived benefits of a web-based data collection center.

Main Methods:

• A secure, web-based program (Clinical Research Web-based Information Center) was utilized for patient enrollment and data collection in a trial for lower pole renal calculi.
• Data input included demographics, clinical information, randomization, treatment, and follow-up, eliminating paper documentation.
• Primary investigators completed a questionnaire regarding their experience with the Internet-based system.

Main Results:

• 112 patients from 21 institutions were successfully randomized via the secure website.
• The majority of investigators reported minimal difficulties navigating the web-based system.
• Investigators highlighted improved convenience, rapid data transmission, and real-time data access as key benefits.

Conclusions:

• Web-based data collection centers enable large, multi-institutional trials with enhanced accuracy and efficiency.
• Centralized data capture and real-time monitoring reduce the burden on individual study sites.
• Secure Internet platforms are invaluable tools for advancing clinical research, ensuring data confidentiality and facilitating prompt analysis.