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Updated: Aug 24, 2026

Particle Agglutination Method for Poliovirus Identification
Published on: April 20, 2011
A polymorphism in the poliovirus receptor gene differs in motor neuron disease
Rebecca Saunderson1, Bing Yu, Ronald J Trent
1Department of Pathology, D06, Central Clinical School, University of Sydney, New South Wales 2006, Australia.
Abstract:
Poliovirus has been implicated in the etiology of sporadic motor neuron disease. DNA polymorphisms in the poliovirus receptor gene (PVR) are associated with persistent poliovirus infection in cell culture. PVR DNA polymorphisms were therefore studied in 110 cases of amyotrophic lateral sclerosis, 30 cases of progressive muscular atrophy (a disorder of lower motor neurons) and 280 normal controls. In exon 2 of PVR the heterozygous Ala67Thr change was detected in 20.0% of progressive muscular atrophy, 11.8% of amyotrophic lateral sclerosis and 6.8% of control subjects. The frequency of the polymorphism was significantly higher in patients with progressive muscular atrophy than in controls. Differences in the poliovirus receptor gene may result in slowly progressive viral cytopathic effects that lead to lower motor neuron forms of motor neuron disease.
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