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[Clinical study on cough variant asthma].

A Niimi1, R Amitani, Y Matsui

  • 1Department of Infection & Inflammation, Kyoto University, Japan.

Nihon Kyobu Shikkan Gakkai Zasshi
|June 1, 1992
PubMed
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Cough variant asthma (CVA) is a type of bronchial asthma presenting solely as chronic cough. This study found peripheral airway obstruction in most CVA patients, suggesting it as a key diagnostic indicator.

Area of Science:

  • Pulmonology
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Chronic cough can be the primary symptom of bronchial asthma, termed cough variant asthma (CVA).
  • Understanding CVA's clinical profile is crucial for accurate diagnosis and management.

Observation:

  • 14 subjects with chronic cough (>8 weeks), without typical asthma symptoms, were evaluated.
  • Diagnostic criteria included bronchial hyperreactivity to methacholine and cough relief with bronchodilators.
  • Atopy was common, with positive skin tests in 10 subjects and elevated serum IgE in 4.

Findings:

  • Peripheral airway obstruction, indicated by decreased V25 values, was observed in 11 of 12 evaluable subjects.
  • FEV1.0% was normal in most subjects, highlighting the sensitivity of V25 in detecting early airway changes.

Related Experiment Videos

  • Respiratory infections preceded CVA onset in 3 subjects, suggesting a potential trigger.

    • Implications:

    • Cough variant asthma diagnosis should consider peripheral airway obstruction, even with normal spirometry.
    • Identifying atopy and potential triggers like infections can aid in CVA management.
    • This research refines the understanding of CVA, differentiating it from other chronic cough causes.