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Updated: Aug 24, 2026

In vitro Assessment of Aortic Regurgitation Using Four-Dimensional Flow Magnetic Resonance Imaging
Published on: February 25, 2022
Reproducibility of the proximal flow convergence method in mitral and tricuspid regurgitation
Georg Grossmann1, Albrecht Hoffmeister, Armin Imhof
1Department of Internal Medicine, Division of Cardiology, University of Ulm, Ulm, Germany. georg.grossmann@medizin.uni-ulm.de
Insights
The flow convergence method for assessing mitral and tricuspid regurgitation shows good reproducibility. This echocardiography technique is reliable regardless of the investigator's experience, aiding in patient follow-up.
Area of Science:
- Cardiology
- Medical Imaging
- Echocardiography
Background:
- Accurate follow-up of patients with mitral regurgitation (MR) and tricuspid regurgitation (TR) is crucial for effective clinical management.
- The flow convergence method is a key echocardiographic technique used in assessing valvular regurgitation severity.
Purpose of the Study:
- To evaluate the reproducibility of the proximal flow convergence method in quantifying mitral and tricuspid regurgitation.
- To determine if investigator experience impacts the reliability of this echocardiographic measurement.
Main Methods:
- Color Doppler echocardiography was used to image the proximal flow convergence region in 83 patients with MR, TR, or both.
- Proximal isovelocity surface area (PISA) radii were measured using aliasing velocities of 27-29 cm/s and 41-43 cm/s.
- Measurements were repeated by the same investigator on different days (intraobserver variability) and by different investigators (interobserver variability).
Main Results:
- Intraobserver variability for PISA radii was low, with 95% ranges of +/- 2.7 mm (for 27-29 cm/s) and +/- 1.8 mm (for 41-43 cm/s).
- Interobserver variability was also low, with 95% ranges of +/- 2.7 mm (for 27-29 cm/s) and +/- 2.4 mm (for 41-43 cm/s).
- Variability was independent of the investigators' experience, with similar findings for both mitral and tricuspid regurgitation.
Conclusions:
- The proximal flow convergence method demonstrates acceptable reproducibility for assessing mitral and tricuspid regurgitation.
- The reliability of the method is not influenced by the experience level of the echocardiography investigator.
- A change in PISA radius greater than 2.7 mm (or 2.4 mm) is needed to indicate a change in regurgitation severity in an individual patient.
Background:
The follow-up of patients with mitral and tricuspid regurgitation is important for their clinical treatment. We aimed to evaluate the reproducibility of the flow convergence method in mitral and tricuspid regurgitation.
Methods:
The proximal flow convergence region was imaged with color Doppler ultrasound scanning echocardiography in 83 patients with mitral regurgitation, tricuspid regurgitation, or both. Proximal isovelocity surface area radii for aliasing velocities of 27 to 29 cm/s and 41 to 43 cm/s were repeatedly measured by the same experienced investigator on different days and by experienced and less experienced investigators at 1 day.
Results:
In mitral regurgitation, the intraobserver variability rate was 0.2% +/- 13.5% (2.8% +/- 13.3%) and the interobserver variability was 0.1% +/- 13.8% (1.7% +/- 18.0%) for an aliasing velocity of 27 to 29 cm/s (41-43 cm/s). For the aliasing velocity of 27 to 29 cm/s (41-43 cm/s), the 95% ranges for change of the proximal isovelocity surface area radii were +/- 2.7 mm (+/- 1.8 mm) for measurements repeated by the same investigator and +/- 2.7 mm ( +/- 2.4 mm) for different investigators. Interobserver variability was independent of the investigators' experience. Similar data were achieved in tricuspid regurgitation.
Conclusions:
The proximal flow convergence method is acceptably reproducible in mitral and tricuspid regurgitation independent of the investigators experience. For the aliasing velocity of 27 to 29 cm/s (41-43 cm/s), the proximal isovelocity surface area radius has to change for >2.7 (2.4) mm before an altered severity of mitral or tricuspid regurgitation in a single patient can be assumed.
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