An efficient asymmetric synthesis of an estrogen receptor modulator by sulfoxide-directed borane reduction

Zhiguo J Song1, Anthony O King, Marjorie S Waters

  • 1Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA. zhiguo_song@merck.com

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Reduction is a simple strategy to convert a carbonyl group to a hydroxyl group. The three major pathways to reduce carbonyls to alcohols are catalytic hydrogenation, hydride reduction, and borane reduction.
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