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Simultaneous Electrical and Mechanical Stimulation to Enhance Cells' Cardiomyogenic Potential
Published on: January 18, 2019
[Heart assist (Vilnius University experience)]
Saulius Miniauskas1, Kestutis Rucinskas, Gintaras Rasimavicius
1Heart Surgery Center, Vilnius University, Santariskiu 2, 2021 Vilnius, Lithuania. cardiosurgery@omni.lt
Insights
Mechanical heart assist devices improve outcomes for patients with advanced heart failure. Intra-aortic balloon pumps show 53% success, while Berlin Heart ventricles offer effective long-term support and bridge to transplantation.
Area of Science:
- Cardiovascular Surgery
- Biomedical Engineering
Background:
- Despite advances in heart surgery, end-stage heart failure remains a significant challenge.
- Mechanical heart assist devices are crucial for managing patients awaiting or recovering from cardiac procedures.
- These devices address hemodynamic compromise in post-cardiotomy and post-transplant patients.
Purpose of the Study:
- To evaluate the efficacy of different mechanical heart assist strategies at the Vilnius University Heart Surgery Center.
- To compare outcomes of intra-aortic balloon pump, extracorporeal membrane oxygenation, and artificial ventricles.
Main Methods:
- Retrospective analysis of 856 patients treated with intra-aortic balloon pumps (IABP) using various insertion techniques.
- Review of 8 patients receiving extracorporeal membrane oxygenation (ECMO) for critical heart and respiratory failure.
- Analysis of 15 Berlin Heart artificial ventricles implanted in 13 patients between 1999 and 2003.
Main Results:
- IABP success rate was 53% overall, with best outcomes (67% discharge) after aorta-coronary bypass surgery.
- IABP success was lower (28%) in heart transplant patients.
- ECMO showed limited success with only 1 of 8 patients successfully weaned.
- Berlin Heart ventricles demonstrated effectiveness as a bridge to transplantation and for long-term support, with 6 patients transplanted and one living over 2 years.
Conclusions:
- Intra-aortic balloon pump is an established and effective method for heart assist, particularly post-CABG.
- Extracorporeal membrane oxygenation has limited application due to low success rates in this cohort.
- Artificial Berlin Heart ventricles represent a promising and effective option for long-term circulatory support and as a bridge to heart transplantation.
Abstract:
Over the last three decades, the results of heart surgery have significantly improved. However, the number of patients at the last stages of heart deficiency has increased. Prevention provided to the patients suffering from heart diseases has improved the quality of their life and increased their lifetime. In spite of that, most of these patients sooner or later need a surgical treatment: heart surgery operation or heart transplantation. The visible damage to haemodynamics of the patients waiting for heart operations and particularly heart transplantations or after them has drawn the focus of heart surgeons to the mechanical systems of heart assist. In many cases they help to cure patients after post-cardiotomic or post-transplant cardiogenic progressive circulation and poly-organic deficiency. They also are regarded effective as a bridge to heart transplantation. In the Heart Surgery Center of Vilnius University, heart assist has been applied since 1976. Contrapulsation with intraaortic balloon pump has been applied to 856 patients, which after heart operations have developed progressive heart deficiency. Four methods of balloon insertion into aorta were used: through the a. iliaca incision (337 cases); through the a. femoralis punction (287 cases); through the ascending aorta (171 cases) and through the ascending aorta using tourniquets (61 cases). The best results were achieved employing intraaortic balloon pump after aorta-coronary bypass surgery: 67% patients were discharged from hospital. The worst results follow heart transplants, as intraaortic balloon pump was successful only to 28% of patients. In general, the total number of patients to whom the heart assist method was successful is 454 (53%). The second heart assist method that has been applied in our centre is the use of extracorporeal membranous oxigenator. It has been employed since 1998 to the patients with the critical respiration and heart deficiency. Extracorporeal membranous oxigenator has been used to 8 patients, to whom pharmaceutical treatment and intraaortic balloon pump were inefficient. Unfortunately, only one of the patients after 105 days was successfully disconnected from the extracorporeal membranous oxigenator, while maintaining his good haemodynamics. The third method of heart assist is the employment of artificial Berlin Heart ventricles. From 1999 up to 2003, 15 artificial Berlin Heart ventricles have been connected to thirteen patients, 7 of them as a bridge to heart transplant. One of the patients has already lived for over 2 years, while 6 patients had heart transplantation. There have been 8 post-cardiotomic patients with incorporated artificial Berlin Heart ventricles. The most experience has been accumulated in the use of intraaortic balloon pump. The fact that 53% of patients were discharged from hospital after such treatment indicates its efficiency. We have little experience in the employment of extracorporeal membranous oxigenator, therefore it is difficult to make conclusions. Whereas the application of Berlin Heart artificial ventricles is an effective method of assist circulation (heart assist), being a bridge to heart transplantation and effective in a long-term treatment.
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