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[Aggressive digital papillary adenocarcinoma: a case report]
A Demarchi1, D Bellis, R Nunziata
1Servizio di Anatomia Patologica e Citologia Diagnostica, Ospedale Giovanni Bosco, Torino. Andrea.Demarchi@aslto4.it
Pathologica
|April 15, 2004
Summary
Aggressive Digital Papillary Adenocarcinoma is a rare, aggressive skin neoplasm. This case highlights its challenging diagnosis and metastatic potential in the acral region.
Area of Science:
- Dermatopathology
- Surgical Pathology
- Oncology
Background:
- Aggressive Digital Papillary Adenocarcinoma (ADPA) is a rare malignant neoplasm.
- ADPA typically presents in the acral regions, often mimicking benign conditions.
Observation:
- A 66-year-old male presented with a large, ulcerated mass on the fifth toe.
- Histopathological examination revealed a solid-cystic structure with papillary features, comedo necrosis, and focal eccrine differentiation.
- Immunohistochemistry demonstrated positivity for cytokeratins AE1/AE3 and 7, Muscle Specific Actin, Vimentin, and EMA.
Findings:
- Chest CT scan identified a solitary pulmonary nodule, suggestive of metastatic disease.
- The clinico-pathological features align with previously reported aggressive digital papillary adenocarcinoma cases.
- The tumor's aggressive nature and metastatic potential were confirmed.
Implications:
- This case underscores the importance of thorough histopathological and immunohistochemical evaluation for acral neoplasms.
- Early detection and understanding the aggressive behavior of ADPA are crucial for patient management.
- Further research into ADPA pathogenesis and treatment strategies is warranted.