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Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling
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Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme

Michel Thérien1, Kathryn Skorey, Robert Zamboni

  • 1Department of Medicinal Chemistry, Merck Frosst Centre for Therapeutic Research, PO Box 1005, Quebec, Pointe Claire--Dorval, Canada H9R 4P8. michel_therien@merck.com

Bioorganic & Medicinal Chemistry Letters
|April 15, 2004
PubMed

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...