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Updated: Aug 10, 2026
08:44
Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
Published on: May 30, 2020
Dobutamine-induced eosinophilia
Osama M El-Sayed1, Rehab R Abdelfattah, Robert Barcelona
1Division of Cardiology, The Ohio State University Medical Center, Columbus, Ohio, USA.
The American Journal of Cardiology
|April 15, 2004
Summary
Dobutamine can cause eosinophilia in patients with heart failure. Promptly stopping the drug can prevent unnecessary testing for hypereosinophilic syndrome.
Area of Science:
- Cardiology
- Hematology
Background:
- Dilated cardiomyopathy and decompensated heart failure are serious conditions often requiring intensive medical management.
- Eosinophilia, an elevated eosinophil count, can be associated with various conditions, including allergic reactions, infections, and hematologic disorders.
Observation:
- A patient with dilated cardiomyopathy and heart failure presented with significant eosinophilia.
- Extensive investigations for hypereosinophilic syndrome were initiated, including a myocardial biopsy.
Findings:
- A second dobutamine infusion (rechallenge) confirmed dobutamine-induced eosinophilia.
- This suggests dobutamine, a commonly used inotropic agent, can precipitate eosinophilia in vulnerable patients.
Implications:
- Given dobutamine's widespread use in critically ill patients, recognizing drug-induced eosinophilia is crucial.
- Discontinuation or substitution of dobutamine can avoid costly and invasive evaluations for hypereosinophilic syndrome.
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