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13:08

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Coagulation factor VII, R353Q polymorphism, and serum choline-containing phospholipids in males at high risk for

Anja S Lindman1, Jan I Pedersen, Harald Arnesen

  • 1Center for Clinical Research, Ullevål University Hospital, Oslo, Norway. anja1@basalmed.uio.no

Thrombosis Research
|April 15, 2004
PubMed

Insights

The FVII R353Q gene polymorphism impacts coagulation factor VII (FVII) levels but shows no significant link to myocardial infarction, cardiovascular disease, or diabetes. Serum phospholipids correlate with FVII levels, independent of genotype.

Area of Science:

  • Cardiovascular Genetics
  • Hemostasis and Thrombosis
  • Molecular Epidemiology

Background:

  • Elevated coagulation factor VII (FVII) levels are linked to increased myocardial infarction (MI) risk.
  • The FVII R353Q gene polymorphism may influence FVII levels and MI risk.

Purpose of the Study:

  • Investigate the FVII R353Q polymorphism's association with MI, cardiovascular disease (CVD), and diabetes.
  • Determine the relationship between the FVII R353Q polymorphism and plasma levels of FVII coagulant activity (FVIIc), FVII antigen (FVIIag), and activated FVII (FVIIa).
  • Examine the association between the FVII R353Q polymorphism and serum choline-containing phospholipids (PC).

Main Methods:

  • Genotyping of the FVII R353Q polymorphism using real-time PCR and melting curve analysis in 560 hypercholesterolemic elderly men.
  • Analysis of FVIIc, FVIIag, FVIIa, and PC levels in a subgroup of 205 individuals.

Main Results:

  • No significant associations were found between the FVII R353Q genotype and MI, CVD, or diabetes.
  • The R353Q polymorphism significantly influenced plasma FVIIag, FVIIc, and FVIIa levels.
  • Serum PC levels correlated positively with FVIIag and negatively with FVIIa, irrespective of genotype.

Conclusions:

  • The FVII R353Q polymorphism affects FVII plasma levels but is not significantly associated with MI, CVD, or diabetes risk.
  • Serum PC levels show a significant association with FVIIag and FVIIa, independent of FVII R353Q genotype.
Abstract

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