[State of renal structure and function in nephrotoxic nephritis treated with uroplasmin]

The experiments were carried out in 14 rabbits in which nephritis Masugi was reproduced. At 15 days of the disease treatment with uroplasmine was started for 7 animals. Proliferative-membranous changes and deposition of fibrin-positive substances in lumens of the capillaries and capsules of the glomeruli, along basal membranes and within cells were found in glomeruli of untreated animals. The structural changes in the kidneys were accompanied by a significant and prolonged decrease in their partial functions. Administration of uroplasmine produced a rapid and stable restoration of both structure and function of the kidneys. It is suggested that uroplasmine not only eliminates the damages caused by the action of thrombin but also inhibits the immune process. On the basis of the experimental data, an immuno-coagulation theory of the pathogenesis of nephritis Masugi is suggested.