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Does systemic inflammation trigger local exercise-induced oxidative stress in COPD?

C Koechlin1, A Couillard, J P Cristol

  • 1Unité Propre de Recherche et d'Enseignement Supérieur Equipe d'Accueil 701, Laboratoire de Physiologie des Interactions, Service Central de Physiologie Clinique, Hospital Arnaud de Villeneuve, 34295 Montpellier, France. christelle_koechlin@hotmail.com

The European Respiratory Journal
|April 16, 2004
PubMed
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Chronic obstructive pulmonary disease (COPD) patients exhibit heightened oxidative stress and inflammation at rest. Exercise exacerbates this oxidative stress, particularly in COPD patients, suggesting underlying inflammatory abnormalities.

Area of Science:

  • Pulmonary Medicine
  • Exercise Physiology
  • Biochemistry

Background:

  • Chronic obstructive pulmonary disease (COPD) is associated with impaired oxidant/antioxidant balance.
  • Systemic inflammation is a common comorbidity in COPD patients.
  • Exercise can potentially exacerbate oxidative stress.

Purpose of the Study:

  • To investigate the time course of oxidative stress and inflammation in COPD patients and healthy subjects after exercise.
  • To explore the relationship between baseline inflammation and exercise capacity in COPD.
  • To determine if exercise induces systemic inflammation in COPD.

Main Methods:

  • 10 COPD patients and 7 healthy subjects underwent dynamic quadriceps endurance exercise.
  • Venous blood samples were collected pre-exercise, immediately post-exercise, and up to 48 hours.

Related Experiment Videos

  • Assessed superoxide anion release, C-reactive protein, TNF-alpha, IL-6, protein oxidation products, and TBARS.

    • Main Results:

    • COPD patients had higher resting superoxide anion, CRP, TNF-alpha, and IL-6 levels.
    • Higher baseline CRP correlated inversely with endurance time in COPD patients.
    • Exercise increased oxidative stress markers (superoxide anion, protein oxidation products) in both groups, but TBARS increased only in COPD patients.
    • Plasma antioxidant and inflammatory cytokine levels remained unchanged post-exercise.

    Conclusions:

    • Elevated baseline systemic inflammation in COPD may contribute to disturbed oxidant/antioxidant balance and exercise-induced oxidative stress.
    • Exercise-induced oxidative stress is present in COPD patients.
    • The lack of exercise-induced systemic inflammation suggests other mechanisms are involved in local exercise-induced oxidative stress in COPD.