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Amino acids and asthma: a case-control study.

A Fogarty1, E Broadfield, S Lewis

  • 1Division of Respiratory Medicine, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, UK. andrew.fogarty@nottingham.ac.uk

The European Respiratory Journal
|April 16, 2004
PubMed
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This study found higher plasma cystine levels in asthma cases, contradicting the hypothesis that it protects against asthma. However, higher plasma glycine levels were associated with a significantly reduced risk of asthma.

Area of Science:

  • Biochemistry
  • Immunology
  • Respiratory Medicine

Background:

  • Amino acids play roles in antioxidant and immune functions relevant to asthma.
  • Previous research suggested potential protective or adverse effects of specific amino acids in asthma etiology.

Purpose of the Study:

  • To investigate the association between plasma amino acid levels and asthma.
  • To test the hypothesis that cystine reduces asthma risk via glutathione metabolism.

Main Methods:

  • A case-control study compared fasting plasma amino acid levels in 89 adults with asthma and 89 matched controls.
  • Participants were adults aged 18-65 years with asthma controlled by inhaled corticosteroids.

Main Results:

  • Contrary to the hypothesis, asthma cases had higher plasma cystine levels than controls.

Related Experiment Videos

  • No significant differences in most amino acids were observed between cases and controls.
  • Higher plasma glycine levels were strongly associated with a reduced risk of asthma (OR 0.30).

    • Conclusions:

    • The study negates the hypothesis that higher plasma cystine levels are protective against asthma.
    • The inverse correlation between plasma glycine and asthma risk warrants further investigation.