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Related Experiment Videos

Positive and negative network correlations in temporal lobe epilepsy.

Hal Blumenfeld1, Kelly A McNally, Susan D Vanderhill

  • 1Department of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8018, USA. hal.blumenfeld@yale.edu

Cerebral Cortex (New York, N.Y. : 1991)
|April 16, 2004
PubMed
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Temporal lobe seizures can cause loss of consciousness due to widespread brain network changes. This study reveals altered cerebral blood flow (CBF) in temporal, subcortical, and association cortex areas during seizures.

Area of Science:

  • Neuroscience
  • Epileptology
  • Medical Imaging

Background:

  • Temporal lobe seizures (TLS) manifest with complex behaviors, including altered consciousness.
  • These phenomena suggest involvement of neural networks extending beyond the temporal lobe.

Purpose of the Study:

  • To investigate cerebral blood flow (CBF) changes during human TLS.
  • To correlate CBF alterations with consciousness levels during seizures.

Main Methods:

  • Single photon emission computed tomography (SPECT) imaging of CBF.
  • Continuous video-electroencephalography (EEG) monitoring during seizures.
  • Analysis of CBF patterns in relation to seizure characteristics and consciousness.

Main Results:

Related Experiment Videos

  • TLS with loss of consciousness showed increased CBF in the temporal lobe and subcortical structures.
  • Widespread CBF decreases were observed in the frontal and parietal association cortex during impaired consciousness.
  • Seizures without loss of consciousness did not exhibit these extensive CBF changes.
  • CBF decreases in association cortex correlated with increased activity in midline structures like the mediodorsal thalamus.

Conclusions:

  • Impaired consciousness in TLS may stem from focal temporal and subcortical network dysfunction.
  • Widespread impairment of association cortex function is linked to consciousness changes in TLS.
  • SPECT imaging can reveal network-level brain alterations during epileptic seizures.