Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Using gene expression profiling to differentiate benign versus malignant thyroid tumors.

Chiara Mazzanti1, Martha A Zeiger, Nick G Costouros

  • 1Surgery Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.

Cancer Research
|April 17, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum: Whole-Body Skeletal Muscle MRI Patterns in Female Dystrophinopathy Carriers.

Neurology. Genetics·2026
Same author

Whole-Body Skeletal Muscle MRI Patterns in Female Dystrophinopathy Carriers.

Neurology. Genetics·2025
Same author

Consensus guideline for the management of peritoneal mesothelioma.

Cancer·2025
Same author

Consensus Guideline for the Management of Peritoneal Mesothelioma.

Annals of surgical oncology·2025
Same author

R01 Funding for Surgeons; What Are the Key Factors for Success?

The Journal of surgical research·2025
Same author

The Road From NIH Training Grants for Surgeons: What is the Return on Investment?

Annals of surgery·2025

This study introduces a gene expression approach for diagnosing thyroid tumors. A 6-gene model accurately distinguishes benign from malignant thyroid lesions, offering a potential new diagnostic tool.

Area of Science:

  • Genomics
  • Oncology
  • Molecular Diagnostics

Background:

  • DNA microarrays enable comprehensive analysis of cellular transcriptional activity.
  • Molecular profiling of cancers offers potential for more relevant diagnoses and treatments than traditional histology.
  • Current methods for diagnosing indeterminate thyroid lesions lack sufficient accuracy.

Purpose of the Study:

  • To develop a gene expression-based approach for differentiating benign from malignant thyroid lesions.
  • To explore the feasibility of a molecular classification system for thyroid tumors.

Main Methods:

  • Utilized DNA microarrays to analyze gene expression profiles in 73 patients with thyroid tumors.
  • Developed and validated gene expression models to distinguish between benign and malignant thyroid lesions.

Related Experiment Videos

Main Results:

  • Successfully developed a 10-gene and a 6-gene model capable of differentiating benign from malignant thyroid tumors.
  • The gene expression models demonstrated efficacy in classifying thyroid lesions based on molecular profiles.

Conclusions:

  • A molecular classification system for thyroid tumors is achievable.
  • Gene expression profiling can serve as a more accurate diagnostic tool for suspicious thyroid lesions.