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R01 Funding for Surgeons; What Are the Key Factors for Success?

Shadin Ghabra1, Lindsay A Demblowski2, Carolina Larrain1

  • 1Surgical Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

The Journal of Surgical Research
|June 10, 2025
PubMed
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Surgeon-scientists with a PhD, prior research training grants (F32/T32), and mentored career awards (K08/K23/K99) show higher R01 grant success rates. These factors are key for independent funding. Keywords: surgeon-scientist, R01 grant, PhD, research training, career award.

Area of Science:

  • Medical Research
  • Surgical Sciences
  • Grant Funding

Background:

  • Surgeon-scientists face declining R01 grant awards compared to non-surgeons.
  • Identifying factors for successful R01 applications is crucial for surgeon-scientists.

Purpose of the Study:

  • To determine key factors associated with successful R01 grant applications for surgeon-scientists.
  • To understand predictors of R01 award success in surgeon-principal investigators.

Main Methods:

  • Analysis of surgeon-scientist principal investigators (PIs) applying for R01 grants (FY2018-2023).
  • Multivariable logistic regression assessed factors: gender, PhD, prior training grants (F32/T32), mentored grants (K08/K23/K99), institution, and h-index.
  • Compared awarded versus non-awarded PIs.
Keywords:
NIH fundingNIH grantNew investigatorR01 grantSurgeon-scientistSurgical research

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Main Results:

  • No significant gender difference in R01 award rates.
  • Success strongly associated with holding a PhD (OR=1.39), prior F32/T32 grants (OR=1.51), and mentored career awards (K08/K23/K99) (OR=2.72).
  • Remaining at the same institution or high h-index (≥40) did not predict success.

Conclusions:

  • PhD degree, previous research training grants, and mentored career awards are critical for surgeon-scientists transitioning to independent R01 funding.
  • These factors enhance the likelihood of securing R01 grants as a first investigator.
  • Focusing on these areas can improve R01 application success for surgeon-scientists.