Related Experiment Videos
Kimura disease: a clinicopathologic study of 21 cases
Hong Chen1, Lester D R Thompson, Nadine S Ives Aguilera
1Department of Hematopathology, Armed Forces Institute of Pathology, Washington, DC 20306, USA.
The American Journal of Surgical Pathology
|April 17, 2004
Summary
Kimura disease, a rare inflammatory condition, affects lymph nodes and salivary glands, often mimicking tumors. This study highlights its occurrence in diverse populations and distinct histological features.
Area of Science:
- Pathology
- Immunology
- Oncology
Background:
- Kimura disease is a rare chronic inflammatory disorder.
- It predominantly affects subcutaneous tissue in the head and neck, with lymphadenopathy and salivary gland involvement.
- Clinically, it can mimic neoplasms and is sometimes confused with angiolymphoid hyperplasia with eosinophilia.
Purpose of the Study:
- To report a comprehensive study of Kimura disease in the United States.
- To describe the clinicopathologic features of 21 cases with nodal involvement.
- To analyze the demographic, clinical, and histological characteristics of Kimura disease.
Main Methods:
- Retrospective analysis of 21 cases with nodal involvement consistent with Kimura disease.
- Review of patient demographics, clinical presentations, and anatomical sites of involvement.
- Histological examination for characteristic features such as follicular hyperplasia, eosinophilic infiltrates, and vascular proliferation.
- Follow-up data analysis for disease recurrence and outcomes.
Main Results:
- The study included 21 patients (18 males, 3 females) aged 8-64 years, with diverse ethnic backgrounds (7 Caucasians, 6 Blacks, 6 Asians, 1 Hispanic, 1 Arabic).
- Posterior auricular and cervical lymph nodes were most commonly involved, with two cases showing salivary gland involvement.
- Peripheral blood eosinophilia was present in 16 cases. Histology revealed follicular hyperplasia, eosinophilic infiltrates, and postcapillary venule proliferation.
- Follow-up data showed recurrence in 3 of 13 patients disease-free and 2 of 4 patients alive with disease.
Conclusions:
- Kimura disease occurs in non-Asians with a similar clinicopathologic presentation as described in Asians.
- Distinct histological features are crucial for differentiating Kimura disease from other conditions like hypersensitivity reactions, drug reactions, and infections.
- Kimura disease is a unique entity with an unknown etiology, characterized by specific histological findings.