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Diabetic neuropathy: pathogenesis and treatment.
1Department of Plastic Surgery, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
Journal of Reconstructive Microsurgery
|April 17, 2004
Summary
Diabetic neuropathy, a severe diabetes complication, arises from multiple factors. Tight glycemic control remains the primary treatment strategy for this condition.
Area of Science:
- Endocrinology
- Neurology
- Metabolic Diseases
Background:
- Diabetic neuropathy is a frequent and severe complication of diabetes mellitus.
- It significantly contributes to patient mortality.
- Pathogenesis involves endoneural metabolism, neurotrophic factors, nerve blood supply, and immune responses.
Purpose of the Study:
- To review and discuss the pathophysiologic mechanisms of diabetic neuropathy.
- To explore current and proposed therapeutic approaches for diabetic neuropathy.
Main Methods:
- Literature review of experimental and clinical studies.
- Analysis of proposed pathophysiologic mechanisms.
- Discussion of therapeutic strategies.
Main Results:
- Key factors in pathogenesis include oxidative stress, polyol pathway, advanced glycation, protein kinase C, and impaired essential fatty acid metabolism.
- Tight glycemic control is identified as the cornerstone of therapy.
Conclusions:
- Understanding the complex mechanisms of diabetic neuropathy is crucial for effective management.
- Glycemic control is the most effective strategy currently available for preventing and treating diabetic neuropathy.