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Testing the autonomic nervous system.

Phillip A Low1

  • 1Department of Neurology, Mayo Foundation, Rochester, Minnesota 55905, USA.

Seminars in Neurology
|April 17, 2004
PubMed
Summary
This summary is machine-generated.

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Clinically available autonomic function tests accurately detect autonomic failure and orthostatic intolerance. While effective, these noninvasive methods primarily assess target tissues, inferring reflex status and potentially influenced by medications.

Area of Science:

  • Autonomic Nervous System Physiology
  • Clinical Neurophysiology
  • Cardiovascular Regulation

Background:

  • Autonomic nervous system disorders, including autonomic failure and orthostatic intolerance, often present subtly.
  • Accurate diagnosis is crucial for effective patient management and treatment.
  • Existing diagnostic methods vary in invasiveness, validation, and directness of measurement.

Purpose of the Study:

  • To review the utility and limitations of currently available noninvasive clinical tests for autonomic function.
  • To highlight the benefits of these tests in identifying milder forms of autonomic dysfunction.
  • To contrast these with more invasive or less validated methods.

Main Methods:

  • Evaluation of sudomotor, cardiovagal, and adrenergic functions using noninvasive clinical tests.

Related Experiment Videos

  • Utilizing an extensive normative database and commercially available equipment.
  • Mention of microneurography and mesenteric bed studies for direct sympathetic nerve recording.

    • Main Results:

    • Noninvasive tests are well-validated, widely used, and aid in recognizing previously missed cases of autonomic failure and orthostatic intolerance.
    • These tests provide significant clinical utility with available resources.
    • Limitations include inference of reflex status from target tissue function and potential medication interference.

    Conclusions:

    • Noninvasive autonomic function tests are valuable diagnostic tools for autonomic disorders.
    • Understanding the limitations, such as indirect reflex assessment, is important for accurate interpretation.
    • More invasive methods offer direct physiological data but are less accessible or validated.