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The thrombospondins.

Josephine C Adams1, Jack Lawler

  • 1Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation, NC1-110, 9500 Euclid Avenue, Cleveland, OH 44195, USA. adamsj@ccf.org

The International Journal of Biochemistry & Cell Biology
|April 20, 2004
PubMed
Summary
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Thrombospondin (TSP) research has evolved significantly since the 1980s. New studies reveal complex TSP roles in cell signaling, adhesion, and disease, expanding knowledge of this protein family.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Thrombospondin-1 (TSP-1) identified as a platelet alpha-granule component and cell adhesion molecule.
  • Discovery of four additional vertebrate TSP gene products expanded the TSP family.
  • Initial classification and functional/evolutionary implications of the new gene family discussed.

Purpose of the Study:

  • Provide a 2004 overview of vertebrate Thrombospondins (TSPs).
  • Discuss advancements in TSP knowledge, including cell signaling, adhesion, and disease associations.
  • Highlight remaining challenges and future perspectives in TSP research.

Main Methods:

  • Literature review and synthesis of existing research on TSPs.
  • Analysis of domain-specific and cell-type specific effects of TSPs.

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  • Examination of genetic associations and disease links involving TSP family members.

    • Main Results:

    • Expanded understanding of TSP functions in cellular processes and tissue homeostasis.
    • Identification of TSP-1 and TSP-2 as key anti-angiogenic agents.
    • Established links between TSP mutations/polymorphisms and human genetic diseases.

    Conclusions:

    • The TSP family encompasses diverse members with complex, context-dependent functions.
    • TSPs play critical roles in angiogenesis, wound healing, and disease pathogenesis.
    • Significant challenges remain in fully elucidating TSP mechanisms and therapeutic potential.