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Primary murine cells as a model for HIV-1 infection
Lars H Lund1, Karl Ljungberg, Britta Wahren
1Microbiology and Tumor Biology Center and Department of Virology, Swedish Institute for Infectious Disease Control, Karolinska Institute, 17182 Solna, Sweden.
AIDS (London, England)
|April 21, 2004
Abstract:
Immortalized and transduced cell lines are traditionally used in model of the HIV-1 life cycle. Primary cells may better represent the tissue of origin and events in vivo. We utilized an HIV-1/murine leukemia A4070 pseudotype virus and human Cyclin T1 to replicate HIV-1 in primary murine cells, and demonstrate that primary murine cells support HIV-1 infection better than immortalized cells.