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Deep brain stimulation and essential tremor.

Kelly E Lyons1, Rajesh Pahwa

  • 1Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. lyons.kelly@att.net

Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society
|April 21, 2004
PubMed
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Deep brain stimulation (DBS) offers an effective surgical option for essential tremor (ET) when medications fail. This treatment provides long-term symptom relief for many patients with disabling ET.

Area of Science:

  • Neurology
  • Neurosurgery

Background:

  • Essential tremor (ET) is a prevalent movement disorder causing functional disability.
  • Approximately 50% of ET patients exhibit medication-resistant symptoms.

Purpose of the Study:

  • To evaluate the efficacy and safety of deep brain stimulation (DBS) for medication-resistant essential tremor (ET).

Main Methods:

  • Surgical implantation of DBS electrodes targeting the ventral intermediate (Vim) nucleus of the thalamus.
  • Assessment of tremor reduction, functional improvement, and adverse events.

Main Results:

  • DBS of the thalamus demonstrates efficacy in treating ET hand tremor, with secondary benefits for voice and head tremor.
  • Long-term studies indicate sustained tremor improvement in a majority of patients.

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  • Stimulation-related adverse effects are typically mild and manageable; hardware complications are infrequent.

    • Conclusions:

    • Deep brain stimulation (DBS) is a safe and effective therapeutic option for patients with disabling, medication-resistant essential tremor (ET).
    • Consideration of DBS should be given to ET patients experiencing significant disability despite medical management.